Thresholds of Genotoxic Carcinogens
  • Author : Takehiko Nohmi
  • Release Date : 20 May 2016
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 224
  • ISBN 13 : 9780128018033

Thresholds of Genotoxic Carcinogens Book Summary

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation

Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens

Author : Takehiko Nohmi,Shoji Fukushima
Publisher : Academic Press
Genre : Medical
Total View : 3025 Views
File Size : 46,9 Mb
Get Book

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even ...

The Cellular Response to the Genotoxic Insult

The Cellular Response to the Genotoxic Insult

Author : Helmut Greim,Richard J. Albertini
Publisher : Royal Society of Chemistry
Genre : Science
Total View : 3139 Views
File Size : 54,9 Mb
Get Book

This book considers the exposure levels at which genotoxins pose a risk and describes the cellular mechanisms used against them....

The Cellular Response to the Genotoxic Insult

The Cellular Response to the Genotoxic Insult

Author : Helmut Greim,Richard Albertini
Publisher : Royal Society of Chemistry
Genre : Science
Total View : 5726 Views
File Size : 54,8 Mb
Get Book

Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of ...

Cancer Risk Assessment

Cancer Risk Assessment

Author : Ching-Hung Hsu,Todd Stedeford
Publisher : John Wiley & Sons
Genre : Science
Total View : 8151 Views
File Size : 51,9 Mb
Get Book

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, ...

Genotoxic Impurities

Genotoxic Impurities

Author : Andrew Teasdale
Publisher : John Wiley & Sons
Genre : Medical
Total View : 7923 Views
File Size : 40,7 Mb
Get Book

This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening ...

Mutagenic Impurities

Mutagenic Impurities

Author : Andrew Teasdale
Publisher : John Wiley & Sons
Genre : Medical
Total View : 1773 Views
File Size : 55,9 Mb
Get Book

Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses ...

Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment

Author : Wai Nang Choy
Publisher : CRC Press
Genre : Medical
Total View : 4743 Views
File Size : 40,8 Mb
Get Book

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices ...

Regulatory Toxicology

Regulatory Toxicology

Author : Franz-Xaver Reichl,Michael Schwenk
Publisher : Springer
Genre : Medical
Total View : 7701 Views
File Size : 51,9 Mb
Get Book

This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This ...