Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Stephen Neidle
  • Release Date : 31 August 2011
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 208
  • ISBN 13 : 9780123751393

Download Therapeutic Applications of Quadruplex Nucleic Acids eBook in PDF, Epub and Kindle

Book Description: The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.

Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids

Author : Stephen Neidle
Publisher : Academic Press
Genre : Science
Get Book

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ...

Quadruplex Nucleic Acids

Quadruplex Nucleic Acids

Author : Jonathan B. Chaires,David Graves
Publisher : Springer
Genre : Science
Get Book

Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell ...

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Author : Anonim
Publisher : Academic Press
Genre : Science
Get Book

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human ...

Medicinal Chemistry of Nucleic Acids

Medicinal Chemistry of Nucleic Acids

Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Genre : Medical
Get Book

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and ...

Quadruplex Nucleic Acids

Quadruplex Nucleic Acids

Author : Stephen Neidle,Shankar Balasubramanian
Publisher : Royal Society of Chemistry
Genre : Science
Get Book

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also ...

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Author : Loutfy H. Madkour
Publisher : Academic Press
Genre : Business & Economics
Get Book

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change ...

G Quadruplex Nucleic Acids

G Quadruplex Nucleic Acids

Author : Danzhou Yang,Clement Lin
Publisher : Humana
Genre : Medical
Get Book

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods ...

Application of Computational Techniques in Pharmacy and Medicine

Application of Computational Techniques in Pharmacy and Medicine

Author : Leonid Gorb,Victor Kuz'min,Eugene Muratov
Publisher : Springer
Genre : Science
Get Book

The proposed volume provides both fundamental and detailed information about the computational and computational-experimental studies which improve our knowledge of how leaving matter functions, the different properties of drugs (including the calculation and the design of new ones), and the creation of completely new ways of treating numerical diseases. Whenever ...

DNA Nanotechnology

DNA Nanotechnology

Author : Chunhai Fan
Publisher : Springer Science & Business Media
Genre : Technology & Engineering
Get Book

DNA nanotechnology: From structure to function presents an overview of various facets of DNA nanotechnology, with a particular focus on their promising applications. This book is composed of three parts. Part I, Elements of DNA Nanotechnology, provides extensive basic information on DNA nanotechnology. Part II, Static and Dynamic DNA Nanotechnology, ...

G Quadruplex Nucleic Acids

G Quadruplex Nucleic Acids

Author : Danzhou Yang,Clement Lin
Publisher : Humana
Genre : Medical
Get Book

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods ...

Oligonucleotide  Therapy  and Applications

Oligonucleotide Therapy and Applications

Author : Salvador F Aliño,Luis Sendra
Publisher : Mdpi AG
Genre : Science
Get Book

Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which ...

Guanine Quartets

Guanine Quartets

Author : Wolfgang Fritzsche,Lea Spindler
Publisher : Royal Society of Chemistry
Genre : Technology & Engineering
Get Book

Guanosine and its derivatives have a high potential for self-recognition and self-assembly, as well as the recognition ability for other biologically important molecules. This book explores in detail these properties with the goal of increasing knowledge of the basic principles of guanosine-assembly, synthesis of new optimised materials and exploration of ...

Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids

Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Publisher : Springer Science & Business
Genre : Science
Get Book

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; ...

Protein Nucleic Acid Interactions

Protein Nucleic Acid Interactions

Author : Phoebe A. Rice,Carl C. Correll
Publisher : Royal Society of Chemistry
Genre : Science
Get Book

The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear ...

Nucleic Acids Chemistry

Nucleic Acids Chemistry

Author : Ramon Eritja
Publisher : Walter de Gruyter GmbH & Co KG
Genre : Science
Get Book

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as ...