Therapeutic Antibody Engineering
  • Author : William R Strohl
  • Release Date : 16 October 2012
  • Publisher : Elsevier
  • Genre : Science
  • Pages : 696
  • ISBN 13 : 9781908818096

Therapeutic Antibody Engineering Book Summary

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering

Author : William R Strohl,Lila M Strohl
Publisher : Elsevier
Genre : Science
Total View : 1532 Views
File Size : 45,6 Mb
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The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that ...

Therapeutic Antibody Engineering  Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

Therapeutic Antibody Engineering Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

Author : William R. Strohl,Lila M. Strohl
Publisher : Woodhead Publishing
Genre : Medical
Total View : 5105 Views
File Size : 43,8 Mb
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The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that ...

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering

Author : W. R. Strohl,Lila M. Strohl
Publisher : Woodhead Pub Limited
Genre : Medical
Total View : 9082 Views
File Size : 42,6 Mb
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The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that ...

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies

Author : Stefan Dübel,Janice M. Reichert
Publisher : John Wiley & Sons
Genre : Science
Total View : 8430 Views
File Size : 49,5 Mb
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Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well ...

Introduction to Antibody Engineering

Introduction to Antibody Engineering

Author : Florian Rüker,Gordana Wozniak-Knopp
Publisher : Springer Nature
Genre : Medical
Total View : 8587 Views
File Size : 53,7 Mb
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This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest ...

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies

Author : Zhiqiang An
Publisher : John Wiley & Sons
Genre : Science
Total View : 9606 Views
File Size : 54,7 Mb
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70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies ...

Antibody Engineering

Antibody Engineering

Author : Thomas Böldicke
Publisher : BoD – Books on Demand
Genre : Medical
Total View : 8358 Views
File Size : 40,5 Mb
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Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display ...

Antibody Engineering

Antibody Engineering

Author : J. Donald Capra
Publisher : Karger Publishers
Genre : Science
Total View : 8062 Views
File Size : 45,7 Mb
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The last decade has witnessed remarkable developments in antibody research and its therapeutic applications. With the methods of molecular biology it is now possible to manipulate the specificities and activities of antibody molecules to generate an almost limitless array of structures for both basic investigations and the clinical setting. The ...