The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre
  • Release Date : 23 July 2020
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 596
  • ISBN 13 : 9780128226421

The Human Mitochondrial Genome Book Summary

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

The Human Mitochondrial Genome

The Human Mitochondrial Genome

Author : Giuseppe Gasparre,Anna Maria Porcelli
Publisher : Academic Press
Genre : Science
Total View : 2742 Views
File Size : 48,5 Mb
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The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, ...

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens

Author : Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 547 Views
File Size : 51,5 Mb
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Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, ...

The Human Mitochondrial Genome

The Human Mitochondrial Genome

Author : Giuseppe Gasparre,Anna Maria Porcelli
Publisher : Academic Press
Genre : Science
Total View : 3013 Views
File Size : 51,7 Mb
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The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, ...

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Author : Herve Seligmann,Ganesh Warthi
Publisher : BoD – Books on Demand
Genre : Medical
Total View : 8011 Views
File Size : 50,9 Mb
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The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. ...

High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics  Function  and Signals of Selection in Cancer

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Publisher : Unknown
Genre : Genetics
Total View : 5129 Views
File Size : 45,8 Mb
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Known as the energy powerhouses of the cell, mitochondria carry their own genomes, and encode for key cellular respiration proteins. Carrying multiple copies per cell, a given mitochondrial DNA (mtDNA) variant can be present at varying proportions, termed heteroplasmy. MtDNA is acquired exclusively through maternal inheritance and becomes stochastically replicated ...

Heritable Human Genome Editing

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Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Genre : Medical
Total View : 8179 Views
File Size : 45,5 Mb
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Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. ...