Second-Generation Cell and Gene-Based Therapies
  • Author : Alain Vertes
  • Release Date : 15 June 2019
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 500
  • ISBN 13 : 0128120347

Second-Generation Cell and Gene-Based Therapies Book Summary

Second-Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalization serves as the only book on the market to bridge basic science, clinical therapy, technology development and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths that will ultimately facilitate clinical delivery of cutting-edge, curative products. Chapters cover hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as enabling technologies, such as gene and genome editing. Additionally, deep dives in product fundamentals, the history of the science, the pathobiology of diseases, the scientific and technological bases, and financing and technology adoption constraints are taken in order to unravel what will shape the cytotherapy industry in 2025 and beyond. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization Perspectives section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

Second Generation Cell and Gene Based Therapies

Second Generation Cell and Gene Based Therapies

Author : Alain Vertes,Nathan J. Dowden,Devyn Smith,Nasib Qureshi
Publisher : Academic Press
Genre : Science
Total View : 1456 Views
File Size : 47,5 Mb
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Second-Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalization serves as the only book on the market to bridge basic science, clinical therapy, technology development and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of ...

Cell and Gene Therapies

Cell and Gene Therapies

Author : Miguel-Angel Perales,Syed A. Abutalib,Catherine Bollard
Publisher : Springer
Genre : Medical
Total View : 5005 Views
File Size : 55,9 Mb
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In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ...

Cell Therapy

Cell Therapy

Author : Adrian Gee
Publisher : Springer Science & Business Media
Genre : Science
Total View : 678 Views
File Size : 46,7 Mb
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Cell Therapy: cGMP Facilities and Manufacturing is the source for a complete discussion of facility design and operation with practical approaches to a variety of day-to-day activities, such as staff training and competency, cleaning procedures, and environmental monitoring. This in-depth book also includes detailed reviews of quality, the framework of ...

Second Generation Cell and Gene Based Therapies

Second Generation Cell and Gene Based Therapies

Author : Alain Vertes,Nathan J. Dowden,Devyn Smith,Nasib Qureshi
Publisher : Academic Press
Genre : Science
Total View : 8780 Views
File Size : 44,9 Mb
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Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept ...

Exploring Novel Clinical Trial Designs for Gene Based Therapies

Exploring Novel Clinical Trial Designs for Gene Based Therapies

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Regenerative Medicine
Publisher : National Academies Press
Genre : Medical
Total View : 1590 Views
File Size : 46,5 Mb
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Recognizing the potential design complexities and ethical issues associated with clinical trials for gene therapies, the Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine held a 1-day workshop in Washington, DC, on November 13, 2019. Speakers at the workshop discussed patient recruitment and selection for gene-based clinical ...

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy

Author : David T. Curiel
Publisher : Academic Press
Genre : Science
Total View : 256 Views
File Size : 47,6 Mb
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Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing ...

Somatic Gene Therapy

Somatic Gene Therapy

Author : P.L. Chang
Publisher : CRC Press
Genre : Science
Total View : 4076 Views
File Size : 40,6 Mb
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As human gene therapy becomes a clinical reality, a new era in medicine dawns. Novel and innovative developments in molecular genetics now provide opportunities to treat the genetic bases of diseases often untreatable before. Somatic Gene Therapy documents these historical clinical trials, reviews current advances in the field, evaluates the ...

Gene and Cell Therapies

Gene and Cell Therapies

Author : Eve Hanna,Mondher Toumi
Publisher : CRC Press
Genre : Medical
Total View : 7766 Views
File Size : 47,5 Mb
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The major advances in the field of biotechnology and molecular biology in the twenty-first century have led to a better understanding of the pathophysiology of diseases. A new generation of biopharmaceuticals has emerged, including a wide and heterogeneous range of innovative cell and gene therapies. These therapies aim to prevent ...