Research in the Biomedical Sciences
  • Author : Michael Curtis
  • Release Date : 01 June 2017
  • Publisher : Academic Press
  • Genre : Uncategorized
  • Pages : 356
  • ISBN 13 : 0128047259

Research in the Biomedical Sciences Book Summary

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a "big picture" perspective that includes the scope of the replicability issue and covers initiatives that have the potential to act as effective solutions Offers real world research context for transparent, replicable experimental design and execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability

Research in the Biomedical Sciences

Research in the Biomedical Sciences

Author : Michael Curtis,Michael Williams
Publisher : Academic Press
Genre : Uncategorized
Total View : 3678 Views
File Size : 40,8 Mb
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Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived ...

Reproducibility and Replicability in Science

Reproducibility and Replicability in Science

Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science
Publisher : National Academies Press
Genre : Science
Total View : 4939 Views
File Size : 52,5 Mb
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One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of ...

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Genre : Medical
Total View : 9521 Views
File Size : 44,8 Mb
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Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their ...

Reproducibility in Biomedical Research

Reproducibility in Biomedical Research

Author : Erwin B. Montgomery
Publisher : Academic Press
Genre : Medical
Total View : 3188 Views
File Size : 42,6 Mb
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Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse ...

Implementing Reproducible Research

Implementing Reproducible Research

Author : Victoria Stodden,Friedrich Leisch,Roger D. Peng
Publisher : CRC Press
Genre : Mathematics
Total View : 4760 Views
File Size : 43,8 Mb
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In computational science, reproducibility requires that researchers make code and data available to others so that the data can be analyzed in a similar manner as in the original publication. Code must be available to be distributed, data must be accessible in a readable format, and a platform must be ...

Reproducible Research with R and RStudio

Reproducible Research with R and RStudio

Author : Christopher Gandrud
Publisher : CRC Press
Genre : Business & Economics
Total View : 4323 Views
File Size : 55,8 Mb
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Praise for previous editions: "Gandrud has written a great outline of how a fully reproducible research project should look from start to finish, with brief explanations of each tool that he uses along the way... Advanced undergraduate students in mathematics, statistics, and similar fields as well as students just beginning ...

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Genre : Science
Total View : 1299 Views
File Size : 40,7 Mb
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Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore ...

Rigor Mortis

Rigor Mortis

Author : Richard Harris
Publisher : Hachette UK
Genre : Medical
Total View : 2123 Views
File Size : 46,7 Mb
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An essential book to understanding whether the new miracle cure is good science or simply too good to be true American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't ...