Protein Homeostasis Diseases
  • Author : Angel L. Pey
  • Release Date : 13 February 2020
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 450
  • ISBN 13 : 9780128191330

Protein Homeostasis Diseases Book Summary

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis Diseases

Protein Homeostasis Diseases

Author : Angel L. Pey
Publisher : Academic Press
Genre : Science
Total View : 7001 Views
File Size : 51,5 Mb
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Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components ...

Protein Homeostasis

Protein Homeostasis

Author : Richard I. Morimoto,Dennis J. Selkoe,Jeffery W. Kelly
Publisher : Unknown
Genre : Science
Total View : 3675 Views
File Size : 43,8 Mb
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Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause ...

Protein Homeostasis  Second Edition

Protein Homeostasis Second Edition

Author : Richard I. Morimoto,Jeffery W. Kelly,F. Ulrich Hartl
Publisher : Perspectives Cshl
Genre : Medical
Total View : 8612 Views
File Size : 42,8 Mb
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The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting ...

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones

Author : Gregory Lloyd Blatch,Adrienne Lesley Edkins
Publisher : Springer
Genre : Medical
Total View : 3656 Views
File Size : 46,9 Mb
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Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client ...

Protein Homeostasis Diseases

Protein Homeostasis Diseases

Author : Angel L. Pey
Publisher : Academic Press
Genre : Science
Total View : 6619 Views
File Size : 41,6 Mb
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Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components ...

Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses

Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses

Author : Axel Mogk,Pierre Genevaux,Kürşad Turgay
Publisher : Frontiers Media SA
Genre : Science
Total View : 9204 Views
File Size : 55,5 Mb
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The Cover Image for This Research Topic is Used With Permission of the Authors and Publishers of the Following Article: Winkler J, Seybert A, König L, Pruggnaller S, Haselmann U, Sourjik V, Weiss M, Frangakis AS, Mogk A, Bukau B.EMBO J. 2010 Mar 3;29(5):910-23. doi: 10.1038/emboj.2009.412. Epub 2010 Jan 21...

Nature s Robots

Nature s Robots

Author : Charles Tanford,Jacqueline Reynolds
Publisher : OUP Oxford
Genre : Science
Total View : 6391 Views
File Size : 41,8 Mb
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Proteins are amazingly versatile molecules. They make the chemical reactions happen that form the basis for life, they transmit signals in the body, they identify and kill foreign invaders, they form the engines that make us move, and they record visual images. All of this is now common knowledge, but ...

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Author : Diana Fernandes Lázaro,Tiago F. Outeiro,Arianna Bellucci,Patrik Brundin
Publisher : Frontiers Media SA
Genre : Uncategorized
Total View : 788 Views
File Size : 49,6 Mb
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review ...