Polymer-Protein Conjugates
  • Author : Gianfranco Pasut
  • Release Date : 30 October 2019
  • Publisher : Elsevier
  • Genre : Technology & Engineering
  • Pages : 512
  • ISBN 13 : 9780444640826

Polymer-Protein Conjugates Book Summary

Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Polymer Protein Conjugates

Polymer Protein Conjugates

Author : Gianfranco Pasut,Samuel Zalipsky
Publisher : Elsevier
Genre : Technology & Engineering
Total View : 1723 Views
File Size : 49,6 Mb
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Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers ...

Polymer Protein Conjugates

Polymer Protein Conjugates

Author : Gianfranco Pasut,Samuel Zalipsky
Publisher : Unknown
Genre : Technology & Engineering
Total View : 5027 Views
File Size : 45,7 Mb
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Polymer-Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design ...

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Author : Francesco M. Veronese
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 9538 Views
File Size : 41,6 Mb
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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the ...

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Publisher : CRC Press
Genre : Science
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Publisher : John Wiley & Sons
Genre : Science
Total View : 3302 Views
File Size : 53,7 Mb
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Explores bioconjugate properties and applications ofpolymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas ofindustry and biomedicine. With its emphasis on synthesis,properties and applications, this book enables readers tounderstand the connection between chemistry and the biologicalapplication of bioconjugated materials. Its detailed descriptionsof methods make it ...

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Publisher : Royal Society of Chemistry
Genre : Science
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This book details polysaccharides and other important biomacromolecules covering their source, production, structures, properties, and current and potential application in the fields of biotechnology and medicine. It includes a systematic discussion on the general strategies of isolation, separation and characterization of polysaccharides and proteins. Subsequent chapters are devoted to polysaccharides ...

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Author : Greg T. Hermanson
Publisher : Academic Press
Genre : Science
Total View : 1984 Views
File Size : 53,7 Mb
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Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details ...

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Publisher : Springer Science & Business Media
Genre : Technology & Engineering
Total View : 3000 Views
File Size : 50,9 Mb
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