Piperidine-Based Drug Discovery
  • Author : Ruben Vardanyan
  • Release Date : 12 June 2017
  • Publisher : Elsevier
  • Genre : Science
  • Pages : 358
  • ISBN 13 : 9780128134283

Download Piperidine-Based Drug Discovery eBook in PDF, Epub and Kindle

Book Description: Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Piperidine Based Drug Discovery

Piperidine Based Drug Discovery

Author : Ruben Vardanyan
Publisher : Elsevier
Genre : Science
Get Book

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related ...

Drug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks

Author : Jie Jack Li,Minmin Yang
Publisher : CRC Press
Genre : Medical
Get Book

Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of ...

Fragment based Drug Discovery

Fragment based Drug Discovery

Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Publisher : John Wiley & Sons
Genre : Medical
Get Book

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of ...

Fragment Based Drug Discovery

Fragment Based Drug Discovery

Author : Steven Howard,Chris Abell
Publisher : Royal Society of Chemistry
Genre : Medical
Get Book

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just ...

Structure based Design of Drugs and Other Bioactive Molecules

Structure based Design of Drugs and Other Bioactive Molecules

Author : Arun K. Ghosh,Sandra Gemma
Publisher : John Wiley & Sons
Genre : Medical
Get Book

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary ...

Imidazole Based Drug Discovery

Imidazole Based Drug Discovery

Author : Shikha Agarwal
Publisher : Elsevier
Genre : Science
Get Book

Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications ...

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery

Author : Robert Stroud,Janet Finer-Moore
Publisher : Royal Society of Chemistry
Genre : Science
Get Book

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of ...

Carbohydrate based Drug Discovery  2 Volume Set

Carbohydrate based Drug Discovery 2 Volume Set

Author : Chi-Huey Wong
Publisher : John Wiley & Sons
Genre : Science
Get Book

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > ...

Synthesis of Essential Drugs

Synthesis of Essential Drugs

Author : Ruben Vardanyan,Victor Hruby
Publisher : Elsevier
Genre : Medical
Get Book

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the ...

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery

Author : Larry Yet
Publisher : John Wiley & Sons
Genre : Medical
Get Book

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that ...

Kinase Drug Discovery

Kinase Drug Discovery

Author : Richard A. Ward,Frederick W. Goldberg
Publisher : Royal Society of Chemistry
Genre : Uncategorized
Get Book

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of ...

Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders

Author : Zoran Rankovic,Richard Hargreaves,Matilda Bingham
Publisher : Royal Society of Chemistry
Genre : Science
Get Book

The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment ...

Diversity Oriented Synthesis

Diversity Oriented Synthesis

Author : Andrea Basso,Seung Bum Park,Lisa Moni
Publisher : Frontiers Media SA
Genre : Uncategorized
Get Book

Has the concept of Diversity Oriented Synthesis remained unchanged over these two decades, or do we observe improvements or deviations from the original guidelines drawn by the pioneers? The aim of this Research Topic is to collect contributions on the state-of-the-art and progress of Diversity Oriented Synthesis, and to foresee ...

Anti fibrotic Drug Discovery

Anti fibrotic Drug Discovery

Author : Jehrod Brenneman,Malliga R. Iyer
Publisher : Royal Society of Chemistry
Genre : Medical
Get Book

Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various ...

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery

Author : Dastmalchi, Siavoush
Publisher : IGI Global
Genre : Medical
Get Book

The role of technology in the medical field has resulted in significant developments within the pharmaceutical industry. Computational approaches have emerged as a crucial method in further advancing drug design and development. Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery presents emerging research on the application of computer-assisted ...