Physiologically Based Pharmacokinetic (PBPK) Modeling
  • Author : Jeffrey W. Fisher
  • Release Date : 20 May 2020
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 346
  • ISBN 13 : 9780128196823

Physiologically Based Pharmacokinetic (PBPK) Modeling Book Summary

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research Authored by expert editors and contributors who are among the best PBPK modelers in the world

Physiologically Based Pharmacokinetic  PBPK  Modeling

Physiologically Based Pharmacokinetic PBPK Modeling

Author : Jeffrey W. Fisher,Jeffery Gearhart,Zhoumeng Lin
Publisher : Academic Press
Genre : Medical
Total View : 5443 Views
File Size : 44,9 Mb
Get Book

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use ...

Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations

Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Author : Sheila Annie Peters
Publisher : John Wiley & Sons
Genre : Medical
Total View : 9354 Views
File Size : 51,9 Mb
Get Book

The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of ...

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling

Author : Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
Publisher : John Wiley & Sons
Genre : Science
Total View : 4181 Views
File Size : 55,6 Mb
Get Book

A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book ...

Drug Delivery Approaches

Drug Delivery Approaches

Author : Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts
Publisher : John Wiley & Sons
Genre : Medical
Total View : 3672 Views
File Size : 46,7 Mb
Get Book

Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and ...

Oral Drug Absorption

Oral Drug Absorption

Author : Jennifer B. Dressman,Christos Reppas
Publisher : CRC Press
Genre : Medical
Total View : 4309 Views
File Size : 46,9 Mb
Get Book

Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR ...

Physics  Pharmacology and Physiology for Anaesthetists

Physics Pharmacology and Physiology for Anaesthetists

Author : Matthew E. Cross,Emma V. E. Plunkett
Publisher : Cambridge University Press
Genre : Medical
Total View : 9705 Views
File Size : 51,5 Mb
Get Book

A quick reference to basic science for anaesthetists, containing all the key information needed for FRCA exams....

Transporters and Drug Metabolizing Enzymes in Drug Toxicity

Transporters and Drug Metabolizing Enzymes in Drug Toxicity

Author : Albert P. Li
Publisher : John Wiley & Sons
Genre : Medical
Total View : 230 Views
File Size : 41,5 Mb
Get Book

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often ...