Organ-on-a-chip
  • Author : Julia Hoeng
  • Release Date : 09 November 2019
  • Publisher : Academic Press
  • Genre : Technology & Engineering
  • Pages : 546
  • ISBN 13 : 9780128172032

Organ-on-a-chip Book Summary

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. Includes case studies of other organs on a chip that have been developed and successfully used Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip

Organ on a chip

Organ on a chip

Author : Julia Hoeng,David Bovard,Manuel Peitsch
Publisher : Academic Press
Genre : Technology & Engineering
Total View : 1556 Views
File Size : 40,9 Mb
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Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently ...

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Organ on a Chip

Author : Marco Rasponi
Publisher : Humana
Genre : Science
Total View : 1774 Views
File Size : 40,6 Mb
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This book provides a collection of microphysiological systems employed for chemical/drug screening and strategies to mimic various physiological conditions. Chapters guide readers through Organ-on-a-Chip( OoC) platforms such as liver, intestine, blood-brain barrier, kidney, vessels, cardiac and skeletal muscles, articular joint, human fat. Additional chapters detail microfabrication technologies used to ...

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Author : Yu-suke Torisawa,Yi-Chung Tung
Publisher : MDPI
Genre : Technology & Engineering
Total View : 6287 Views
File Size : 45,9 Mb
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Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, ...

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Author : Masoud Mozafari
Publisher : Woodhead Publishing
Genre : Medical
Total View : 1229 Views
File Size : 51,6 Mb
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Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread ...

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Author : Kathrin Herrmann,Kimberley Jayne
Publisher : Human-Animal Studies
Genre : Philosophy
Total View : 5627 Views
File Size : 48,9 Mb
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Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches....

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Author : Margarita Stoytcheva,Roumen Zlatev
Publisher : BoD – Books on Demand
Genre : Science
Total View : 8624 Views
File Size : 51,8 Mb
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The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to ...

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Author : Chip Jones
Publisher : Simon and Schuster
Genre : History
Total View : 585 Views
File Size : 42,7 Mb
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The Immortal Life of Henrietta Lacks meets Get Out in this “startling…powerful” (Kirkus Reviews) investigation of racial inequality at the core of the heart transplant race. In 1968, Bruce Tucker, a black man, went into Virginia’s top research hospital with a head injury, only to have his heart taken ...

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Author : Shi-Cong Tao,Shang-Chun Guo,Wei Seong Toh,Nuno M. Neves,Owen Gareth Davies
Publisher : Frontiers Media SA
Genre : Science
Total View : 7936 Views
File Size : 47,5 Mb
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Existing culture systems have a limited ability to reproduce the complicated and dynamic microenvironment of a functioning organ. To solve the issues of conventional culture techniques, multidisciplinary researchers, involving medical doctors, stem cell and developmental biology experts, engineers and physical scientists, have emerged to innovate methods and devices. A microfluidic ...