Novel Designs of Early Phase Trials for Cancer Therapeutics
  • Author : Shivaani Kummar
  • Release Date : 22 May 2018
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 234
  • ISBN 13 : 9780128125700

Novel Designs of Early Phase Trials for Cancer Therapeutics Book Summary

Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development

Novel Designs of Early Phase Trials for Cancer Therapeutics

Novel Designs of Early Phase Trials for Cancer Therapeutics

Author : Shivaani Kummar,Chris Takimoto
Publisher : Academic Press
Genre : Medical
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File Size : 54,6 Mb
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Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses ...

Novel Designs of Early Phase Trials for Cancer Therapeutics

Novel Designs of Early Phase Trials for Cancer Therapeutics

Author : Shivaani Kummar,Chris Takimoto
Publisher : Academic Press
Genre : Medical
Total View : 223 Views
File Size : 48,5 Mb
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Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses ...

Phase I Oncology Drug Development

Phase I Oncology Drug Development

Author : Timothy A. Yap,Jordi Rodon,David S. Hong
Publisher : Springer Nature
Genre : Medical
Total View : 1014 Views
File Size : 42,6 Mb
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This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials ...

Phase I Cancer Clinical Trials

Phase I Cancer Clinical Trials

Author : Elizabeth A. Eisenhauer,Christopher Twelves,Marc Buyse
Publisher : Oxford University Press
Genre : Medical
Total View : 1740 Views
File Size : 43,9 Mb
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Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies ...

Platform Trial Designs in Drug Development

Platform Trial Designs in Drug Development

Author : Zoran Antonijevic,Robert A. Beckman
Publisher : CRC Press
Genre : Mathematics
Total View : 2539 Views
File Size : 50,9 Mb
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Platform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to life-altering medicines for people suffering from serious illnesses, possibly at lower cost. Currently, the cost of drug development is unsustainable. ...

Transforming Clinical Research in the United States

Transforming Clinical Research in the United States

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Genre : Medical
Total View : 9519 Views
File Size : 42,7 Mb
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An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls ...

Statistical Approaches in Oncology Clinical Development

Statistical Approaches in Oncology Clinical Development

Author : Satrajit Roychoudhury,Soumi Lahiri
Publisher : CRC Press
Genre : Mathematics
Total View : 6119 Views
File Size : 48,7 Mb
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Statistical Approaches in Oncology Clinical Development : Current Paradigm and Methodological Advancement presents an overview of statistical considerations in oncology clinical trials, both early and late phase of development. It illustrates how novel statistical methods can enrich the design and analysis of modern oncology trials. The authors include many relevant real ...

The Drug Development Paradigm in Oncology

The Drug Development Paradigm in Oncology

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Genre : Medical
Total View : 6356 Views
File Size : 45,9 Mb
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Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and ...