Epigenetic Gene Expression and Regulation
  • Author : Suming Huang
  • Release Date : 19 October 2015
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 482
  • ISBN 13 : 9780128004715

Epigenetic Gene Expression and Regulation Book Summary

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Genre : Science
Total View : 6328 Views
File Size : 55,9 Mb
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Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can ...

Translating MicroRNAs to the Clinic

Translating MicroRNAs to the Clinic

Author : Jeffrey Laurence
Publisher : Academic Press
Genre : Science
Total View : 409 Views
File Size : 46,5 Mb
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Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the ...

Essentials of Noncoding RNA in Neuroscience

Essentials of Noncoding RNA in Neuroscience

Author : Davide De Pietri Tonelli
Publisher : Academic Press
Genre : Science
Total View : 4733 Views
File Size : 52,9 Mb
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Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are ...

MicroRNAs in Diseases and Disorders

MicroRNAs in Diseases and Disorders

Author : Philip V Peplow,Bridget Martinez,George A Calin,Aurora Esquela-Kerscher
Publisher : Royal Society of Chemistry
Genre : Science
Total View : 6696 Views
File Size : 53,6 Mb
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From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive ...

Epigenetic Biomarkers and Diagnostics

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Author : José Luis García-Giménez
Publisher : Academic Press
Genre : Science
Total View : 2545 Views
File Size : 54,8 Mb
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Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based ...

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs

Author : Jayprokas Chakrabarti,Sanga Mitra
Publisher : Academic Press
Genre : Medical
Total View : 1097 Views
File Size : 52,7 Mb
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Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and ...

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Genre : Science
Total View : 4269 Views
File Size : 51,8 Mb
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Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have ...

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases

Author : Loo Keat Wei
Publisher : Translational Epigenetics
Genre : Business & Economics
Total View : 8355 Views
File Size : 50,7 Mb
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Computational Epigenetics and Diseases provides a comprehensive and cutting edge knowledge of computational epigenetics in human diseases, written by leading scientists in this evolving field. In particular, the major computational tools, databases and strategies for computational epigenetics analysis, for example DNA methylation, histone modifications ad microRNA, are summarized, in the ...