Intrinsically Disordered Proteins
  • Author : Birthe B. Kragelund
  • Release Date : 23 July 2021
  • Publisher : Humana
  • Genre : Science
  • Pages : 951
  • ISBN 13 : 1071605267

Intrinsically Disordered Proteins Book Summary

The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims to help scientists with different backgrounds to further their investigations into these fascinating and dynamic molecules. Chapter 24 is available open access under a CC BY 4.0 license via link.springer.com. Chapters “40 and 42 ” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins

Author : Birthe B. Kragelund,Karen Skriver
Publisher : Humana
Genre : Science
Total View : 8872 Views
File Size : 53,7 Mb
Get Book

The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins

Author : Nicola Salvi
Publisher : Academic Press
Genre : Science
Total View : 8454 Views
File Size : 52,8 Mb
Get Book

Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins

Author : Vladimir N. Uversky
Publisher : Springer
Genre : Science
Total View : 6496 Views
File Size : 42,5 Mb
Get Book

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their ...

Dancing protein clouds  Intrinsically disordered proteins in health and disease  Part A

Dancing protein clouds Intrinsically disordered proteins in health and disease Part A

Author : Anonim
Publisher : Academic Press
Genre : Science
Total View : 8891 Views
File Size : 49,6 Mb
Get Book

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their ...

Instrumental Analysis of Intrinsically Disordered Proteins

Instrumental Analysis of Intrinsically Disordered Proteins

Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Genre : Science
Total View : 9985 Views
File Size : 42,6 Mb
Get Book

Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis ...

Structure and Function of Intrinsically Disordered Proteins

Structure and Function of Intrinsically Disordered Proteins

Author : Peter Tompa,Alan Fersht
Publisher : CRC Press
Genre : Science
Total View : 3950 Views
File Size : 46,9 Mb
Get Book

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered ...

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Author : Isabella C. Felli,Roberta Pierattelli
Publisher : Springer
Genre : Science
Total View : 1914 Views
File Size : 41,8 Mb
Get Book

This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in ...

Intrinsically Disordered Protein Analysis

Intrinsically Disordered Protein Analysis

Author : Vladimir N. Uversky,A. Keith Dunker
Publisher : Springer
Genre : Science
Total View : 8711 Views
File Size : 51,8 Mb
Get Book

Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods ...