Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
  • Author : Shuguang Ma
  • Release Date : 09 July 2020
  • Publisher : Elsevier
  • Genre : Science
  • Pages : 708
  • ISBN 13 : 9780128200193

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Book Description: Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Identification and Quantification of Drugs  Metabolites  Drug Metabolizing Enzymes  and Transporters

Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters

Author : Shuguang Ma,Swapan Chowdhury
Publisher : Elsevier
Genre : Science
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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on ...

Identification and Quantification of Drugs  Metabolites and Metabolizing Enzymes by LC MS

Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS

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Publisher : Elsevier
Genre : Science
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As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing ...

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Author : Martin F. Fromm,Richard B. Kim
Publisher : Springer Science & Business Media
Genre : Medical
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Author : Albert P. Li
Publisher : John Wiley & Sons
Genre : Medical
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Genre : Technology & Engineering
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Publisher : Bentham Science Publishers
Genre : Science
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Publisher : Frontiers Media SA
Genre : Uncategorized
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When Ehrlich discovered the first evidence of the blood-brain barrier in 1885, he probably did not perceive the Great Wall that remained hidden from consciousness inside the central nervous system. Ehrlich had observed that acidic vital dyes did not stain the brain if they were injected into the blood stream. A ...

Transporters and Drug Metabolizing Enzymes in Drug Toxicity

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Author : Albert P. Li
Publisher : John Wiley & Sons
Genre : Medical
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This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often ...

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Publisher : John Wiley & Sons
Genre : Science
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Publisher : John Wiley & Sons
Genre : Medical
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Publisher : John Wiley & Sons
Genre : Medical
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Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, ...

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Author : Hye Suk Lee,Kwang-Hyeon Liu
Publisher : MDPI
Genre : Medical
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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I ...

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