Histone Modifications in Therapy
  • Author : Pedro Castelo-Branco
  • Release Date : 21 August 2020
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 490
  • ISBN 13 : 9780128167403

Histone Modifications in Therapy Book Summary

Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists

Histone Modifications in Therapy

Histone Modifications in Therapy

Author : Pedro Castelo-Branco,Carmen Jeronimo
Publisher : Academic Press
Genre : Science
Total View : 2544 Views
File Size : 46,7 Mb
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Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant ...

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy

Author : Steven Gray
Publisher : Academic Press
Genre : Medical
Total View : 1379 Views
File Size : 51,6 Mb
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Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the ...

Epigenetic Therapy of Cancer

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Author : Michael Lübbert,Peter A. Jones
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 252 Views
File Size : 42,9 Mb
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The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA ...

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Author : Shabir Ahmad Ganai
Publisher : Springer Nature
Genre : Medical
Total View : 7533 Views
File Size : 42,5 Mb
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This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. ...

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Author : Susan M. Gasser,En Li
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 9061 Views
File Size : 53,9 Mb
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Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system ...