Pharmaceutical Toxicology in Practice
  • Author : Alberto Lodola
  • Release Date : 31 March 2011
  • Publisher : John Wiley & Sons
  • Genre : Medical
  • Pages : 280
  • ISBN 13 : 9780470922729

Pharmaceutical Toxicology in Practice Book Summary

This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book proceeds to detail international regulations (including the impact of the new REACH standards for chemical safety), interdisciplinary interactions among scientists in drug development, steps in toxicity testing, and risk management. Further, the book covers the methods of genetic toxicology (assays, genomics, in vivo screening) as a complement to “traditional” toxicology in the risk assessment and risk management of pharmaceuticals.

Pharmaceutical Toxicology in Practice

Pharmaceutical Toxicology in Practice

Author : Alberto Lodola,Jeanne Stadler
Publisher : John Wiley & Sons
Genre : Medical
Total View : 2842 Views
File Size : 54,5 Mb
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This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study ...

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Publisher : CRC Press
Genre : Medical
Total View : 8566 Views
File Size : 41,9 Mb
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As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have ...