GPCRs
  • Author : Beata Jastrzebska
  • Release Date : 11 September 2019
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 500
  • ISBN 13 : 9780128167281

GPCRs Book Summary

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

GPCRs

GPCRs

Author : Beata Jastrzebska,Paul S.-H. Park
Publisher : Academic Press
Genre : Science
Total View : 4852 Views
File Size : 48,8 Mb
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GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric ...

G Protein Coupled Receptors

G Protein Coupled Receptors

Author : Anonim
Publisher : Academic Press
Genre : Science
Total View : 9670 Views
File Size : 43,6 Mb
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G-Protein-Coupled Receptors, Part B, 2nd Edition, Volume 149, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers Optical Approaches for Visualization of Arrestin Binding to Muscarinic Receptors, Luciferase Reporter Assay for ...

Modelling of GPCRs

Modelling of GPCRs

Author : Andrea Strasser,Hans-Joachim Wittmann
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 9833 Views
File Size : 46,5 Mb
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G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ...

Neuropeptide GPCRs in neuroendocrinology

Neuropeptide GPCRs in neuroendocrinology

Author : Jae Young Seong,Hubert Vaudry
Publisher : Frontiers E-books
Genre : Diseases of the endocrine glands. Clinical endocrinology
Total View : 1241 Views
File Size : 41,9 Mb
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The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. ...

Adhesion   GPCRs

Adhesion GPCRs

Author : Simon Yona,Martin Stacey
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 8918 Views
File Size : 52,7 Mb
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Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into ...

The Physiology and Pharmacology of Leucine rich Repeat GPCRs

The Physiology and Pharmacology of Leucine rich Repeat GPCRs

Author : Brian J. Arey,James A. Dias
Publisher : Frontiers Media SA
Genre : Diseases of the endocrine glands. Clinical endocrinology
Total View : 8479 Views
File Size : 45,9 Mb
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G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of ...

Ligand Design for G Protein coupled Receptors  Volume 30

Ligand Design for G Protein coupled Receptors Volume 30

Author : Didier Rognan,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Publisher : John Wiley & Sons
Genre : Science
Total View : 1367 Views
File Size : 54,9 Mb
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1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation ...

The G Protein Coupled Receptors Handbook

The G Protein Coupled Receptors Handbook

Author : Lakshmi A. Devi
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 3962 Views
File Size : 42,6 Mb
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A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They ...