Gap Junctions in the Brain
  • Author : Ekrem Dere
  • Release Date : 12 December 2012
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 304
  • ISBN 13 : 9780124159273

Download Gap Junctions in the Brain eBook in PDF, Epub and Kindle

Book Description: Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants

Gap Junctions in the Brain

Gap Junctions in the Brain

Author : Ekrem Dere
Publisher : Academic Press
Genre : Medical
Get Book

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides ...

Gap Junctions in the Nervous System

Gap Junctions in the Nervous System

Author : David C. Spray,Rolf Dermietzel
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional ...

Gap Junctions in the Brain

Gap Junctions in the Brain

Author : Ekrem Dere
Publisher : Academic Press
Genre : Medical
Get Book

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides ...

Connexin Cell Communication Channels

Connexin Cell Communication Channels

Author : Ernesto Oviedo-Orta,Brenda R. Kwak,William Howard Evans
Publisher : CRC Press
Genre : Science
Get Book

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks—connexins—have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune ...

Gap Junctions

Gap Junctions

Author : E.L. Hertzberg
Publisher : Elsevier
Genre : Science
Get Book

The objective in editing this volume was twofold: to provide a reasoned overview of the field as well as to furnish one that provided this overview within the context of the intellectual boundaries of those who initially attempted to define the purview of gap junction research. The latter objective has ...

Gap Junctions in Development and Disease

Gap Junctions in Development and Disease

Author : Elke Winterhager
Publisher : Springer Science & Business Media
Genre : Health & Fitness
Get Book

The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease. Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function. Starting with a comprehensive review ...

Discovering the Brain

Discovering the Brain

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Genre : Medical
Get Book

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to ...

Cell Cell Channels

Cell Cell Channels

Author : František Baluška,Dieter Volkmann,Peter W. Barlow
Publisher : Springer Science & Business Media
Genre : Science
Get Book

he biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. TThis concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as ...

An Introduction to Modeling Neuronal Dynamics

An Introduction to Modeling Neuronal Dynamics

Author : Christoph Börgers
Publisher : Springer
Genre : Mathematics
Get Book

This book is intended as a text for a one-semester course on Mathematical and Computational Neuroscience for upper-level undergraduate and beginning graduate students of mathematics, the natural sciences, engineering, or computer science. An undergraduate introduction to differential equations is more than enough mathematical background. Only a slim, high school-level background ...

Connexin30  Expression in Astrocytes  Co localization with Connexin43 at Gap Junctions  and Late Developmental Appearance in Rat Brain

Connexin30 Expression in Astrocytes Co localization with Connexin43 at Gap Junctions and Late Developmental Appearance in Rat Brain

Author : Anonim
Publisher : Unknown
Genre : Uncategorized
Get Book

Evidence has been presented (Nagy et al., 1997a) that in addition to connexin43, astrocytes express a second connexin, suggested to be connexin30 (Cx30), a recently discovered member of the family of gap junction proteins. A Cx30 specific antibody was developed and used to confirm this observation using Western blots and ...

Astrocytes and Epilepsy

Astrocytes and Epilepsy

Author : Jacqueline A. Hubbard,Devin K. Binder
Publisher : Academic Press
Genre : Medical
Get Book

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". ...

PH and Brain Function

PH and Brain Function

Author : Kai Kaila,Bruce R. Ransom
Publisher : John Wiley & Sons
Genre : Medical
Get Book

"PH and Brain Function offers thorough coverage of this increasingly important area of research, beginning with the fundamental concepts, which include methodological and theoretical issues such as the measurement of pH and the concept of pH in neurobiology. It explores aspects of regulation and modulation of intracellular pH in brain ...