Drug-like Properties: Concepts, Structure Design and Methods
  • Author : Li Di
  • Release Date : 26 July 2010
  • Publisher : Elsevier
  • Genre : Science
  • Pages : 552
  • ISBN 13 : 9780080557618

Drug-like Properties: Concepts, Structure Design and Methods Book Summary

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Drug like Properties  Concepts  Structure Design and Methods

Drug like Properties Concepts Structure Design and Methods

Author : Li Di,Edward H Kerns
Publisher : Elsevier
Genre : Science
Total View : 2408 Views
File Size : 51,9 Mb
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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance ...

Drug like Properties

Drug like Properties

Author : Edward Harvel Kerns,Li Di
Publisher : Unknown
Genre : Medical
Total View : 6900 Views
File Size : 54,7 Mb
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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance ...

Optimizing the  Drug Like  Properties of Leads in Drug Discovery

Optimizing the Drug Like Properties of Leads in Drug Discovery

Author : Ronald Borchardt,Edward Kerns,Michael Hageman,Dhrien Thakker,James Stevens
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 5071 Views
File Size : 42,6 Mb
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This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines ...

Drug Design Strategies

Drug Design Strategies

Author : David J. Livingstone,Andrew M. Davis
Publisher : Royal Society of Chemistry
Genre : Medical
Total View : 6832 Views
File Size : 44,6 Mb
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Shows how different parts of the drug discovery process have developed, with particular emphasis on quantitative aspects and possible future progress....

Textbook of Drug Design and Discovery  Third Edition

Textbook of Drug Design and Discovery Third Edition

Author : Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen
Publisher : CRC Press
Genre : Medical
Total View : 5796 Views
File Size : 48,5 Mb
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Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from ...

Metabolism  Pharmacokinetics and Toxicity of Functional Groups

Metabolism Pharmacokinetics and Toxicity of Functional Groups

Author : Dennis A Smith
Publisher : Royal Society of Chemistry
Genre : Medical
Total View : 7683 Views
File Size : 45,5 Mb
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Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist. This outstanding book, aimed at postgraduate medicinal chemists and those working in industry, fills this gap in the literature. Written by medicinal chemists and ADMET scientists with a combined experience of ...

Drug like Properties

Drug like Properties

Author : Li Di,Edward H. Kerns
Publisher : Academic Press
Genre : Uncategorized
Total View : 9965 Views
File Size : 51,6 Mb
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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like ...

Pattern Recognition in Bioinformatics

Pattern Recognition in Bioinformatics

Author : Visakan Kadirkamanathan,Guido Sanguinetti,Mark Girolami,Mahesan Niranjan,Josselin Noirel
Publisher : Springer
Genre : Science
Total View : 7453 Views
File Size : 48,9 Mb
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This book constitutes the refereed proceedings of the Fourth International Workshop on Pattern Recognition in Bioinformatics, PRIB 2009, held in Sheffield, UK, in September 2009. The 38 revised full papers presented were carefully reviewed and selected from numerous submissions. The topics covered by these papers range from image analysis for biomedical data to ...