DNA Methylation and Complex Human Disease
  • Author : Michel Neidhart
  • Release Date : 11 August 2015
  • Publisher : Academic Press
  • Genre : Science
  • Pages : 552
  • ISBN 13 : 9780127999203

DNA Methylation and Complex Human Disease Book Summary

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease

Author : Michel Neidhart
Publisher : Academic Press
Genre : Science
Total View : 551 Views
File Size : 44,6 Mb
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DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as ...

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease

Author : Michel Neidhart
Publisher : Academic Press
Genre : Science
Total View : 7032 Views
File Size : 42,7 Mb
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DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia and autoimmunity. DNA methylation is also discussed as ...

Network Medicine

Network Medicine

Author : Joseph Loscalzo
Publisher : Harvard University Press
Genre : Medical
Total View : 8102 Views
File Size : 52,6 Mb
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Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases....

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases

Author : Loo Keat Wei
Publisher : Translational Epigenetics
Genre : Business & Economics
Total View : 1762 Views
File Size : 48,5 Mb
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Computational Epigenetics and Diseases provides a comprehensive and cutting edge knowledge of computational epigenetics in human diseases, written by leading scientists in this evolving field. In particular, the major computational tools, databases and strategies for computational epigenetics analysis, for example DNA methylation, histone modifications ad microRNA, are summarized, in the ...

Beyond Our Genes

Beyond Our Genes

Author : Raffaele Teperino
Publisher : Springer Nature
Genre : Medical
Total View : 5436 Views
File Size : 52,8 Mb
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The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This ...

Epigenetic Epidemiology

Epigenetic Epidemiology

Author : Karin B. Michels
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 4921 Views
File Size : 40,9 Mb
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The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly ...

Epigenetics in Human Disease

Epigenetics in Human Disease

Author : Trygve O. Tollefsbol
Publisher : Academic Press
Genre : Medical
Total View : 5157 Views
File Size : 44,5 Mb
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of ...

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Genre : Science
Total View : 4048 Views
File Size : 50,5 Mb
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Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have ...