Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi
  • Release Date : 16 April 2019
  • Publisher : Academic Press
  • Genre : Business & Economics
  • Pages : 470
  • ISBN 13 : 9780128147054

Animal Models in Cancer Drug Discovery Book Summary

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Genre : Business & Economics
Total View : 2852 Views
File Size : 48,6 Mb
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Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on ...

Tumor Models in Cancer Research

Tumor Models in Cancer Research

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Genre : Medical
Total View : 9003 Views
File Size : 50,6 Mb
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The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the ...

Translational Animal Models in Drug Discovery and Development

Translational Animal Models in Drug Discovery and Development

Author : Xinkang Wang
Publisher : Bentham Science Publishers
Genre : Science
Total View : 124 Views
File Size : 52,8 Mb
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Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene ...

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Genre : Business & Economics
Total View : 1554 Views
File Size : 42,5 Mb
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Animal Models in Cancer Drug Discovery covers recent developments in tumor model systems for translational cancer research. Virtually all types of existing and emerging tumor models in use by the research community are discussed. Areas covered include the latest organoid derived models and newer genetic models. Additionally, the book discusses ...

Mouse Models for Drug Discovery

Mouse Models for Drug Discovery

Author : Gabriele Proetzel,Michael V. Wiles
Publisher : Humana
Genre : Medical
Total View : 7302 Views
File Size : 41,9 Mb
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As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse ...

Unravelling Cancer Signaling Pathways  A Multidisciplinary Approach

Unravelling Cancer Signaling Pathways A Multidisciplinary Approach

Author : Kakoli Bose,Pradip Chaudhari
Publisher : Springer Nature
Genre : Medical
Total View : 9789 Views
File Size : 41,8 Mb
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Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction ...

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Genre : Science
Total View : 3977 Views
File Size : 43,8 Mb
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Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore ...

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Genre : Medical
Total View : 5857 Views
File Size : 45,7 Mb
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Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking ...