A Practical Guide to Rational Drug Design
  • Author : Sun Hongmao
  • Release Date : 01 October 2015
  • Publisher : Woodhead Publishing
  • Genre : Uncategorized
  • Pages : 292
  • ISBN 13 : 0081000987

A Practical Guide to Rational Drug Design Book Summary

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. Discusses various tactics applicable to daily drug design Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops Offers a unique viewpoint on drug discovery research due to the author's cross-discipline education background Explores the author's rich experiences in both pharmaceutical and academic settings

A Practical Guide to Rational Drug Design

A Practical Guide to Rational Drug Design

Author : Sun Hongmao
Publisher : Woodhead Publishing
Genre : Uncategorized
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File Size : 54,5 Mb
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This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high ...

A Practical Guide to Rational Drug Design

A Practical Guide to Rational Drug Design

Author : Sun Hongmao
Publisher : Woodhead Publishing
Genre : Medical
Total View : 9886 Views
File Size : 49,5 Mb
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This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high ...

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Publisher : John Wiley & Sons
Genre : Science
Total View : 6719 Views
File Size : 43,8 Mb
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Publisher : Springer Nature
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Total View : 6019 Views
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Pharmacological biotechnology is applied to and used to study drug development, working mechanisms, diagnosis, and therapies. This textbook covers the whole range of experiments related to pharmacology. It also contains basic laboratory safety guidelines along with the basic calculations and formulas used in a laboratory. Each chapter starts with an ...